Three-dimensional genome folding in vertebrates, such as the formation of topologically associating domains (TADs), depends on cohesin-mediated loop extrusion, yet its regulation in plants remains unresolved. Using Hi-C and Micro-C, here we show that Arabidopsis cohesin regulator PDS5A is a key modulator of chromatin l...
Sofia Tzourtzou, Zhi-Dan Wang, Sarah Leuchtenberg et al.· The Plant Cell· 0 citations
Evidence is discussed supporting a model in which plant 3D genome organization arises from the interplay between three major regulatory layers: chromatin states defined by histone modifications, transcription factor-mediated regulatory interactions, and cohesin-dependent chromatin extrusion.
Ze-Zhao Su, Zhi-Dan Wang, D. Latrasse et al.· Current opinion in plant bio...· 0 citations
It is found that BRI1 contains an exonic enhancer (EE), which is essential to establish the spatial BRI1 expression pattern, and its disruption restricts BRI1 expression and impairs BRI1-dependent root growth, linking exon-encoded regulatory information and development.
Raúl Denia-Mondéjar, Paula Brunot-Garau, Xing Ma et al.· bioRxiv· 0 citations
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