Preserving independence in older adults is a public health priority. Lifestyle interventions can prevent physical disability, but whether their efficacy is influenced by multimorbidity profiles is unclear. In this post hoc analysis of the SPRINTT randomized trial (NCT02582138), we investigated whether the efficacy of a...
D. L. Vetrano, Caterina Gregorio, F. Triolo et al.· Nature Aging· 0 citations
Higher diet quality is associated with favourable levels of blood-based biomarkers in older adults, with distinct associations within the metabolic and inflammatory domains, supporting the role of diet in promoting healthier aging.
Rachel Ann DaCosta, Caterina Gregorio, A. Calderón-Larrañaga et al.· BMC Medicine· 0 citations
Higher blood biomarker levels of AD are associated with accelerated trajectories of GS decline and earlier onset of mobility limitations, suggesting a faster decline in GS may reflect underlying neurodegeneration and indicate changes in brain health.
Javier Leal-Martín, G. Grande, Caterina Gregorio et al.· Journal of Cachexia, Sarcope...· 0 citations
Easily accessible blood-based biomarkers of AD may be linked to subsequent faster cognitive decline in the general older population, with patterns suggesting some heterogeneity across biomarkers and that individual characteristics may influence clinical interpretation.
E. J. Laukka, I. Ekström, Martina Valletta et al.· JAMA Network Open· 0 citations
In cognitively unimpaired older adults, elevated blood p-tau217 was linked to faster shrinkage in AD-specific brain regions, whereas NfL and GFAP were associated with more widespread atrophy, with NfL also associated with accelerated WMH accumulation.
Martina Valletta, D. L. Vetrano, E. J. Laukka et al.· Annals of Neurology· 0 citations
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