Author

D. L. Robertson

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Open access Jul 2026

Flu Mutation Explorer: an Interactive Platform for Mapping Host Adaptation Mutations in Influenza A Viruses

The Flu Mutation Explorer is presented, an interactive web application that combines large-scale influenza phylogenies with a manually curated database of reported mammalian adaptation mutations, to enable the exploration and interpretation of IAV genetic variation.

Laura Mojsiejczuk, Derek W. Wright, R. Gifford et al. · bioRxiv · 0 citations

Open access Jul 2026

Protein language models learn underlying mutation biases alongside fitness landscapes

A parameter sweep is implemented to explicitly couple empirical nucleotide mutational supply from PLM-assessed amino acid substitution pseudo-probabilities across evolutionary forecasting tasks and finds that base PLMs implicitly learn generic nucleotide-level mutational constraints, an effect strongly amplified by virus-specific fine-tuning.

O. MacLean, Kieran D. Lamb, Spyros Lytras et al. · bioRxiv · 0 citations