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Author

D. Kufe

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Open access Aug 2026

M1C is a druggable target for NSCLC KRAS G12C mutant tumors resistant to KRAS inhibitors.

It is reported that treatment of NSCLC KRAS G12C cells with sotorasib induces M1C expression by a STAT1-dependent pathway, and M1C drives the sotorasib resistant phenotype by NF-κB-mediated induction of the epithelial-mesenchymal transition and a mucinous gene program.

Shinkichi Takamori, Naoki Haratake, Atrayee Bhattacharya et al. · 1 citation

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