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Author

Dragomir B. Krastev

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2 papers indexed here

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Open access Sep 2026

PUM3 is an essential suppressor of replication stress in homologous recombination deficient breast cancer

Most Triple Negative Breast Cancers (TNBCs) are p53 mutant high-grade invasive ductal carcinomas with a basal-like transcriptional programme. A large proportion of TNBCs also have mutation signatures indicating defective homologous recombination (HR) DNA repair. While HR deficiency is mutagenic and oncogenic, it can al...

V. Amodeo, D. Weekes, Nicolae Balan et al. · 0 citations
Open access Aug 2026

Mitotic single-stranded DNA suppression by DDIAS.

It is reported that DDIAS is a DNA-binding effector of the CIP2A pathway in human cells and proposed that DDIAS defines a mitotic DNA repair system downstream of CIP2A that mitigates the threat of mitotic ssDNA for genome integrity.

Yibo Xue, Faisal Bin Rashed, Daniel Y. L. Mao et al. · 1 citation

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