A narrative review aims to provide an up-to-date overview of available and emerging imaging tools that may help discriminate activity from damage across organ systems involved in SSc, with a specific focus on early fibrotic and inflammatory manifestations.
A. Lescoat, Laura Ross, C. Bergmann et al.· Rheumatology· 0 citations
Systemic sclerosis (SSc) is a multifaceted systemic autoimmune disease, characterised by the interplay of vascular alterations, immune dysregulation, and fibrosis. The molecular changes and the clinical presentation of SSc are highly heterogeneous and vary considerably between individual patients. This heterogeneity ha...
Jörg H. W. Distler, S. Assassi, A. Gabrielli et al.· Annals of the Rheumatic Dise...· 0 citations
Abatacept selectively modulates CD319/SLAMF7-expressing cytotoxic T cells and suppresses associated pro-fibrotic and pro-inflammatory cytokines, particularly in the fibroproliferative subtype, where CD319+ T cell reductions correlate with clinical improvement.
Mikel Gurrea-Rubio, Laura A. Cooney, Kohei Maeda et al.· Arthritis & Rheumatology· 0 citations
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