D. Kalra

Coronary Plaque Burden in South Asian Adults

Background South Asian (SA) adults have disproportionately high rates of premature coronary artery disease, yet conventional risk calculators may not fully capture coronary plaque burden. Objectives We analyzed the DILWALE (DIL Wellness and Arterial Health Longitudinal Evaluation) registry to quantify coronary plaque b...

Non-HDL Cholesterol as a Predictor of Coronary Atherosclerosis in South Asians: A Narrative Review

Genetic testing for dilated and arrhythmogenic cardiomyopathies - A primer for cardiologists.

Genetic testing for dilated and arrhythmogenic cardiomyopathies (DCM, ACM) is increasingly important as it can refine diagnosis, inform risk stratification, and enable cascade screening. However, its clinical application remains challenging due to variable penetrance, phenotypic overlap, and marked genetic heterogeneit...

Skeletal Muscle Dysfunction in Heart Failure: Mechanistic Insights and Therapeutic Implications.

Exercise intolerance is a hallmark of heart failure (HF) and a strong predictor of morbidity and mortality. Accumulating evidence suggests that alterations in skeletal muscle (SkM) structure and metabolism are key contributors to exercise intolerance in patients with HF. These alterations include reduced muscle mass, i...

SGLT2 Inhibitors and Cardiovascular Outcomes in Patients With Fabry Disease: Observations From a Federated Research Network.

BACKGROUND AND AIM Fabry disease (FD) is frequently complicated by renal impairment and cardiovascular events; however, evidence on sodium-glucose cotransporter-2 inhibitors (SGLT2i) in this population is scarce. Accordingly, we assessed the association between SGLT2i exposure and cardiovascular outcomes in adults with...

Finerenone in Heart Failure with Preserved Ejection Fraction: Expanding the Role of Non-steroidal Mineralocorticoid Receptor Antagonists

Finerenone is a promising therapy for HFpEF/HFmrEF, particularly in patients with the cardiovascular-kidney-metabolic syndrome (CKM).

Joint associations of Interleukin-6 and apolipoprotein B with major adverse cardiovascular events in the UK biobank.

IL-6 and ApoB were independently associated with cardiovascular events, with atherogenic lipoprotein burden predominating for MI and inflammatory signaling for cardiovascular and all-cause death.