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Author

D. Jonigk

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Open access Aug 2026

Single-cell and spatial transcriptomics resolve airway obliteration in bronchiolitis obliterans syndrome

BOS engages structural-cell circuits largely shared with RAS and fibrotic lung diseases, but along an airway-centered rather than parenchyma-centered axis, and shared structural programs may therefore be targetable across CLAD phenotypes.

Jannik Ruwisch, Hande Yilmaz, Leonard Christian et al. · 0 citations
Open access Jul 2026

Aberrant and Ectopic Cell Populations in Restrictive Allograft Syndrome after Lung Transplantation.

Considering the multifaceted differences of RAS and idiopathic pulmonary fibrosis, a surprising general principle of an entity-spanning composition of the fibrotic niche by aberrant basaloid cells localized at the fibrotic edge, ectopic COL15A1+ pVECs and CTHRC1+ fibrotic fibroblasts is revealed.

L. Leiber, Leonard Christian, L. Neubert et al. · 0 citations
#protein folding Open access Aug 2026

Human iPSC-cardiomyocyte-aggregate cell therapy in non-human primates and correlation of heart recovery with contractile and electrophysiological cardiomyocyte properties

This study demonstrates the successful production and injection of human induced pluripotent stem cell cardiomyocyte aggregates into infarcted cynomolgus monkey hearts, resulting in substantial, structured human grafts three months after cell transplantation, and uncoupling of cardiomyocyte production from transplantat...

I. Gruh, Andreas Martens, S. Cebotari et al. · 0 citations

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