Author

D. Horst

3 papers indexed here

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Preprint Aug 2026

Concept-based explanation of gene expression prediction from H&E images

Recent advances in pathology foundation models have enabled accurate prediction of spatial transcriptomics (ST) from routine H&E images. However, existing explainability methods for vision transformer (ViT)-based models are largely limited to local heatmaps and do not reveal how morphological concepts contribute to ST...

Amos Muench, J. Thielmann, Reduan Achtibat et al. · 0 citations

Open access Sep 2026

Tumor-versus-non-tumor T cell enrichment supported by single-cell and spatial phenotyping enables antigen-agnostic prioritization of candidate tumor-reactive TCRs

Introduction Tumor-reactive T cell receptors (TCRs) are promising candidates for the manufacturing of safe and effective adoptive TCR-T cell therapies, but their efficient identification remains a major challenge. We previously established an antigen-agnostic TCR-repertoire analysis workflow that prioritizes candidate...

V. Seitz, J. Franzen, K. Gennermann et al. · bioRxiv · 0 citations

Open access Aug 2026

Mesenchymal R-spondin 3 promotes an immunogenic tumor microenvironment with adaptive immune resistance in human gastric adenocarcinoma.

Positive associations between RSPO3 expression and inflammation suggest that RSPO3 signaling contributes to shaping the immune microenvironment of human intestinal-type GC, a phenotype specific to intestinal-type GC.

Anne-Sophie Fischer, Alexander Arnold, Hilmar Berger et al. · Gastric Cancer · 0 citations