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Author

D. Higgins

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Review Open access Oct 2026

Ferroptosis-Mediated Radiosensitization in Glioblastoma: Preclinical Insights and Translational Opportunities

Glioblastoma (GBM) remains the most common and most aggressive primary malignant brain tumor in adults, and despite maximal safe resection with adjuvant radiotherapy (RT) and temozolomide (TMZ), median overall survival remains 12–15 months with near-universal recurrence. Ferroptosis, an iron-dependent form of regulated...

Olivia E. Gilbert, H. F. Fowler, Asish Madarapu et al. · 0 citations
Review Oct 2026

Emerging Platform Trials for the Treatment of Newly Diagnosed and Recurrent Glioblastoma.

Glioblastoma (GBM) remains highly morbid despite maximal safe resection, radiotherapy, and chemotherapy, prompting the expansion of clinical investigation. This review examines 4 emerging therapeutic strategies for newly diagnosed and recurrent GBM that address major biological barriers to treatment: tumor immunosuppre...

Deveney Franklin, D. Higgins · 0 citations

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