D. Gonzalez-Martinez

Suppression of EGFR signaling and drug-induced potentiation are widespread features of oncogenic RTK fusions.

Regulation of cancer cells by their environment contributes to tumorigenesis and drug response, though the extent to which the oncogenic state can alter a cell's perception of its environment is not clear. EML4-ALK is a receptor tyrosine kinase (RTK) fusion oncoprotein that suppresses transmembrane EGFR signaling in ca...