Bone marrow (BM) is a complex and dynamic structure in which spatial relationships influence cell behavior, signaling, and function. Because of this, understanding the full dynamics of cellular interactions requires complementary spatial techniques that preserve and map the architecture of cell populations in situ. Des...
Lorea Campos-Dopazo, Miguel Cócera, P. Aguirre-Ruiz et al.· Journal of Visualized Experi...· 0 citations
The authors report a transfer learning framework designed to integrate scRNA-seq data across species by combining RNA expression with embeddings from protein language models and general-purpose language models, establishing Unify as a powerful method for comparative single-cell genomics and evolutionary biology.
Hua-Wen Zhong, Wenkai Han, Guo-Xin Cui et al.· Nature Communications· 0 citations
Despite immune-cell infiltration being a hallmark of multiple sclerosis (MS), the interplay between the periphery and central nervous system immune responses is still incompletely characterized. We performed single-cell transcriptomic and V(D)J sequencing of paired blood and cerebrospinal fluid (CSF) immune cells from...
Nils Hallén, S. J. Fernandes, S. Rad Pour et al.· bioRxiv· 0 citations
The RNA-DNA interactome is established as a new genome regulatory layer that defines and maintains cellular identity and behavior and is shown to be highly dynamic yet reproducibly organized in cell-type specific networks.
A. Lambolez, P. Sahlén, Wenjing Kang et al.· bioRxiv· 1 citation
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