Open access
Oct 2026
Cell segmentation is a critical yet under-standardized step in spatial transcriptomics, directly affecting cell identity assignment, spatial organization and downstream biological interpretation. Despite rapid advances in spatial transcriptomics technologies, systematic evaluations of segmentation methods across platfo...
Xabier Martínez-de-Morentin, S. Khan, A. Maillo et al.
· Nature Methods · 0 citations
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Open access
Jul 2026
The authors report a transfer learning framework designed to integrate scRNA-seq data across species by combining RNA expression with embeddings from protein language models and general-purpose language models, establishing Unify as a powerful method for comparative single-cell genomics and evolutionary biology.
Hua-Wen Zhong, Wenkai Han, Guo-Xin Cui et al.
· Nature Communications · 0 citations
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Open access
Aug 2026
The RNA-DNA interactome is established as a new genome regulatory layer that defines and maintains cellular identity and behavior and is shown to be highly dynamic yet reproducibly organized in cell-type specific networks.
A. Lambolez, P. Sahlén, Wenjing Kang et al.
· bioRxiv · 1 citation
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