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Author

D. Evans

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Open access Sep 2026

Vpu protects HIV-infected cells from antibody-dependent cellular phagocytosis by counteracting tetherin.

It is found that Vpu mutations that impair tetherin antagonism also increase the susceptibility of HIV-infected cells to antibody-dependent cellular phagocytosis (ADCP), and the antiviral activity of tetherin may be amplified in vivo by Fc-mediated antibody effector functions and therefore much greater than initially a...

Brian J. Snow, Nida K. Keles, Ahmed Ali et al. · 0 citations
Open access Aug 2026

Long-term depletion of KIR3DL01+ NK cells by adeno-associated viral-vectored antibody delivery alters chronic SIV infection

It is suggested that KIR3DL01+ NK cells contribute to the inhibition of SIV replication during chronic infection, and the feasibility of AAV-vectored antibody delivery for long-term, perhaps indefinite depletion of a lymphocyte subset in a nonhuman primate model is demonstrated.

Kjell Sandstrom, Grace N. Hagedorn, Sean C Robinson et al. · 0 citations

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