Author

D. Eizirik

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Open access Sep 2026

A Novel PD-L1 Splice Isoform Modulates β Cell Communication in Response to Interferon Signaling

β cell expression of the immune checkpoint ligand PD-L1 (encoded by CD274) limits autoimmune β cell destruction in type 1 diabetes (T1D). β cell display PD-L1 not only at the cell surface but also secreted on extracellular vesicles (EVs), which bind PD-1 and restrain CD8+ T cell activation. β cell IFN signaling is an e...

Chaitra Rao, Fei Huang, Saptarshi Roy et al. · bioRxiv · 0 citations

Sep 2026

Shared non-HLA genetic architecture across diverse ancestries links insulin secretion and resistance to type 1 diabetes.

The findings support the existence of a shared non-HLA genetic architecture that may link type 1 diabetes susceptibility to both impaired insulin secretion and insulin resistance, providing preliminary genetic evidence for their convergent pathogenic mechanisms.

Qi Fu, Ke-Yao Wang, Min Shen et al. · Diabetologia · 0 citations

Aug 2026

Engineering Lipid Nanoparticles through Integrated Compositional and Ligand Targeting Enhances β Cell-Directed RNA Delivery.

A dual-targeting LNP engineering strategy that integrates high-throughput compositional screening with surface conjugation of β cell-specific targeting ligands to enable selective gene delivery to pancreatic β cells is developed and establishes a versatile platform for RNA therapeutics and gene-editing applications in...

Di Yu, Yining Zhu, A. Roca-Rivada et al. · ACS Nano · 1 citation