Open access
Sep 2026
Exogenous IFN-α delivered as an intranasal adjunct to systemic vaccination directs vaccine-specific T-cell responses to the upper respiratory tract
Respiratory infectious diseases remain a major global health burden, sustained by ongoing community transmission. Licensed respiratory vaccines are predominantly systemically administered, which elicit vaccine-induced antigen-specific circulating immunity, but fail to protect the primary site of initial infection and o...
R. Fraser, Jürgen Schwarze, D. Dockrell
· Frontiers in Immunology · 0 citations