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D. Di Carlo

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Oct 2026

Hydrogel compartmentalization enables flow cytometric selection of engineered yeast producing complex natural products.

Saccharomyces cerevisiae is a powerful chassis for biosynthesis of plant-derived natural products, but optimizing multi-enzyme pathways remains bottlenecked by the lack of scalable screens for small molecules with weak to no fluorescence. Here we present a colony-level, fluorescence-activated cell sorting (FACS) workfl...

Moriel J. Dror, Cayden Williamson, Yi Tang et al. · 0 citations
#artificial intelligence Review Sep 2026

BioEVAL: A global, multi-institutional benchmark of large language and multimodal models for bioengineering

Diverse cloud-scale foundation/multimodal models and locally deployable models suitable for inference on consumer-grade GPUs are evaluated, achieving the highest accuracy of up to 90% on MCQs, similarity score of 0.72 on literature synthesis, and accuracy of 80% on a small sample of multimodal reasoning questions, with...

Shun Ye, V. C. Suja, Chen-Long Li et al. · 0 citations
Open access Aug 2026

Hydrogel formulation controls size-dependent accumulation of proteins and nanoparticles in PEG microparticles

Hydrogels are widely used in sensing, delivery, and tissue engineering because their transport properties can be tuned through material design. However, while hydrogel permeability is often characterized using small molecules, many practical applications depend on the uptake and retention of much larger species, includ...

Alyssa Arnheim, Ian Morales, Andrew Tran et al. · 0 citations
Preprint Aug 2026

Whole Blood-Based Point-of-Care Assay for Single-Tier Lyme Disease Testing

A whole-blood multiplexed vertical flow assay (WB-xVFA) that performs single-tier Lyme serology directly from 50 microliter of whole blood is presented, demonstrating the feasibility of rapid, near-patient whole-blood Lyme serology.

Mihye Lee, R. Ghosh, Artem Goncharov et al. · 0 citations

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