Author

D. Dhull

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Review Open access Sep 2026

The P2X7R-NLRP3 inflammasome axis in Alzheimer’s disease and therapeutic potential of synthetic and plant-derived natural compounds: A review

Alzheimer’s disease is a prevalent neurodegenerative disease that is characterized by synaptic dysfunction followed by neuronal loss. The core pathological mechanisms of Alzheimer’s disease include the extracellular deposition of amyloid beta (Αβ) plaques and intracellular neurofibrillary tangle deposits inside the b...

Rishabh Goswami, Nidhi Sharma, V. Jhawat et al. · Asian Pacific Journal of Tro... · 0 citations

Review Jul 2026

INHIBITION OF P2X7R-DRIVEN NLRP3 INFLAMMASOME ACTIVATION BY Dalbergia sissoo IN EXPERIMENTAL ALZHEIMER’S DISEASE

The present review aims to delve into the potential mechanism of action of Dalbergia sissoo in Alzheimer’s disease, focusing on the interaction between the P2X7 receptor and NLRP3 inflammasome.

Rishabh Goswami, A. Rai, D. Dhull et al. · Journal of Dynamics and Cont... · 0 citations

Review Jul 2026

NEUROTHERAPEUTIC POTENTIAL OF CUSCUTA REFLEXA (AMARBAEL): A MULTI-TARGETED HERBAL MODULATOR OF THE P2X7–NLRP3 INFLAMMASOME AXIS IN ALZHEIMER’S DISEASE

This review critically examines the neurotherapeutic potential of Cuscuta reflexa as a multi-target modulator of the P2X7–NLRP3 inflammasome axis in Alzheimer’s disease and proposes a mechanistic framework through which Cuscuta reflexa may attenuate chronic neuroinflammation, preserve synaptic integrity, and support ne...

Komal Bhiduri, Abhinash Saini, D. Dhull et al. · Journal of Dynamics and Cont... · 0 citations