Comparative characterization of novel lipid nanoparticle adjuvants reveals distinct immunogenicity and reactogenicity profiles
Rational design of adjuvants that simultaneously increase immunogenicity and reduce reactogenicity remains a challenge for protein vaccine development. Conventional adjuvants, like aluminum salts, and oil-in-water emulsions (like MF59, AS03, and AddaVax), work well to increase antibody titers but have variable abilit...