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D. Daniele

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Open access Sep 2026

In Vitro Exploration of Antisense and Splice-Switching Oligonucleotide Multimers Using an Engineered Peptide Scaffold

Antisense oligonucleotides (ASOs) are potent therapeutics that enable precise RNA modulation. However, efficient delivery to tissues and cell types remains a major challenge. Multimerization, linking multiple ASOs to form large constructs, represents a promising strategy to explore delivery and pharmacokinetics modul...

Quentin Vicentini, Elena Grobecker, D. Daniele et al. · 0 citations
Open access Aug 2026

Optimizing nucleic acid delivery using PF14 peptide and lipid nanoparticle systems

The importance of formulation optimization in improving nucleic acid delivery is highlighted and practical insights for enhancing peptide- and lipid-based therapeutic platforms are provided.

D. Daniele, Z. Hein, O. Saher et al. · 0 citations

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