Open access
Oct 2026
SH3YL1-TLR5 complex-mediated vicious cycle contributes to FSGS pathogenesis
Summary The mechanisms underlying focal segmental glomerulosclerosis (FSGS), particularly podocyte damage, remain unclear. We found that patients with FSGS have significantly elevated serum and urine levels of SH3YL1, especially in more severe cases. Adriamycin stimulates SH3YL1 secretion, which induces proinflammatory...
Hye Eun Lee, J. Ghee, Eun Jung An et al.
· iScience · 0 citations