Autoimmune rheumatic diseases (ARDs) such as systemic lupus erythematosus and rheumatoid arthritis (RA) arise from aberrant immune responses that lead to chronic inflammation and tissue damage. Conventional treatments, including biological disease-modifying antirheumatic drugs (bDMARDs), often provide limited effective...
A. V. Poznyak, V. P. Karagodin, D. Borodko et al.· International Journal of Dru...· 0 citations
This paper advocates for a multi-target therapeutic approach in SS, aiming to mitigate the intricate cytokine network and restore glandular function, ultimately improving patient outcomes.
A. V. Poznyak, A. Vatlin, D. Borodko et al.· International Journal of Dru...· 0 citations
Atherosclerosis is a chronic immune–inflammatory disease of the arterial wall in which antigen-presenting cells (dendritic cells, macrophages and B cells) present locally generated antigens, such as oxidized low-density lipoprotein, to plaque-infiltrating T cells. Full T-cell activation requires costimulation through t...
A. Blagov, Alexey Vatlin, D. Borodko et al.· International Journal of Mol...· 0 citations
BACKGROUND
Mitochondria play a key role in the regulation of inflammatory processes. It is well established that mitochondria contain their own mitochondrial DNA (mtDNA), which displays a substantially higher frequency of polymorphisms compared to the nuclear genome. To maintain mitochondrial functionality, cells emplo...
A. D. Zhuravlev, N. Nikiforov, S. Verkhova et al.· Frontiers in Bioscience· 0 citations
This narrative review summarizes current data on the role of desialylation of low-density lipoproteins (LDL) as a key initiating mechanism of atherogenesis that precedes oxidative modification. The structural and functional significance of sialic acid in apolipoprotein B-100 is considered, and the enzymes of the sialid...
Tatyana I. Kovyanova, V. P. Karagodin, D. Borodko et al.· Biomolecules· 0 citations
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of morbidity and mortality worldwide, driven by complex interactions among dyslipidemia, chronic inflammation, insulin resistance, endothelial dysfunction, and gut microbiome-derived metabolites. This review synthesizes mechanistic and clinical ev...
Tatyana I. Kovyanova, M. Nerush, V. P. Karagodin et al.· Biomedicines· 0 citations
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