People living with HIV (PLWH) on suppressive antiretroviral therapy (ART) can face non-AIDS complications, partially driven by chronic immune activation. To define immune perturbations during ART-suppressed viral infection, we performed longitudinal single-cell transcriptomic and plasma proteomic analyses of rhesus mac...
Maanasa Kaza, B. Varco-Merth, G. McElfresh et al.· Cell Reports· 0 citations
The majority of persons living with HIV-1 who discontinue antiretroviral therapy (ART) demonstrate viral rebound, but the tissue-level events that lead to rebound viremia remain poorly understood. Here we report the origin, dynamics, and correlates of viral rebound in 16 rhesus macaques (RMs) infected with molecularly...
Irena V. King, Malika Aid, Emek Kose et al.· Science Translational Medici...· 0 citations
Monoclonal antibodies hold significant promise for preventing HIV infection in infants and children. However, global access remains constrained by the high production costs and infrastructure requirements associated with complex mammalian cell manufacturing platforms. Alternative expression systems, including plant-bas...
T. Tsekoa, Lusisizwe Kwezi, P. Pillay et al.· Frontiers in Pediatrics· 0 citations
Using systems serology, it is possible to create an assay that quantifies a human receptor’s binding levels to a virus receptor binding protein in the presence of neutralizing antibodies. For example, human influenza A virus predominantly binds to alpha 2’6-linked sialic acids, while avian influenza A prefers alp...
Lindsay R. McManus, Qixin Wang, Kate S. Levine et al.· Journal of Immunology· 0 citations
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