MYC is one of the most frequently dysregulated oncogenic drivers across many cancers, yet direct therapeutic targeting has remained difficult because its function is mediated by disordered regions and transient protein-protein interactions. Here we design proteins that bind epitopes within regions of MYC whose sequence...
N. McNamara-Bordewick, Ke-Jia Wu, Yu-Long Su et al.· bioRxiv· 0 citations
N-linked glycans are ubiquitous post-translational modifications that mediate diverse biological processes, including cell signaling and adhesion, molecular recognition, and host-pathogen interactions. Despite their importance, N-linked glycans have largely remained beyond the reach of biomolecular design due to a lack...
Margaret C. Lunn-Halbert, J. D. Allen, Rohith Krishna et al.· bioRxiv· 0 citations
Three-dimensional protein crystals are ordered, porous macroscopic materials with potential applications in catalysis, biosensing, and biomedicine. However, most protein crystals are obtained by empirical screening, providing limited control over the lattice architecture, pore geometry or component composition that det...
Zhe Li, Shun-Zhi Wang, W. Sheffler et al.· bioRxiv· 0 citations
OutLAST Regulators are designed proteins that reprogram critical T cell signaling pathways to enhance functional persistence and are implemented as compact genetic modules compatible with standard viral vectors and cell therapy manufacturing processes, creating a powerful platform for programming new functions into enh...
S. Boyken, Sean A. Merillat, Robert A. Langan et al.· bioRxiv· 0 citations
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