Open access
Sep 2026
Siglec-1-targeting single domain antibodies block or enhance pathogen binding to dendritic cells
High-affinity single domain antibodies, (also known as VHHs or Nanobodies) that allo- or orthosterically modulate ligand binding of Siglec-1 are identified and may serve as broad-spectrum pathogen blocking agents.
H. J. Brink, A. Affandi, S. Man et al.
· Journal of Biological Chemis... · 0 citations