Abstract IA05: Biology and therapeutic targeting of NUP98 fusion oncoprotein condensates
NUP98 fusion oncoproteins (FOs) define a high-risk subset of pediatric acute myeloid leukemia, for which more effective therapies are urgently needed. NUP98 FOs involve the intrinsically disordered, N-terminal region of NUP98 and the C-terminal region of one of over 30 identified partner genes. These partner genes co...