Cynthia H. Chiu

Parallel In Vivo Screening of Gene Knockout and Activation in the Mouse Mammary Gland.

Forward genetics screens are routinely employed to perturb thousands of genetic elements in a pooled fashion with the goal of producing large-scale genotype-to-phenotype maps. While often carried out in cell culture systems, accumulating evidence supports that in vivo screens have the power to unveil new biology that c...