Cui-Qing Ma

NETs drive CD4⁺ T cell dysfunction in sepsis via mitochondrial ROS and impaired calcium signalling

Sepsis is a life-threatening condition with high mortality, in which sepsis-induced immunosuppression—characterized by CD4+ T cell dysfunction and apoptosis—worsens clinical outcomes. The mechanistic link between neutrophil extracellular traps (NETs) and CD4+ T cell fate in sepsis remains poorly elucidated. We integrat...