The NLRP3 inflammasome as a bridge between myocardial infarction and depression: mechanisms, bidirectional link, and therapeutic potential
Myocardial infarction (MI) and depression frequently co-occur and form a bidirectional relationship that worsens patient outcomes, with inflammation serving as a core mechanism linking these two disorders. The NLRP3 inflammasome, a key component of the innate immune system, plays a pivotal role in sterile inflammatory...