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Author

Craig Blackstone

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Review Open access Sep 2026

Phenotypic Spectrum and Clinical Approach to Early-Onset Hereditary Spastic Paraplegia.

BACKGROUND Early-onset hereditary spastic paraplegias (HSPs) are an underrecognized cause of progressive spasticity, gait impairment, and movement disorders in children and young adults. HSPs frequently mimic cerebral palsy or genetic, metabolic, and acquired disorders, resulting in diagnostic delay. Their broad phenot...

Jenny L. Wilson, Craig Blackstone, D. Ebrahimi-Fakhari et al. · 0 citations

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