Viral infections are common across the human lifespan, yet their molecular effects on human neurons remain poorly characterized. We present a mass spectrometry (MS)-based proteomic dataset profiling human induced pluripotent stem cell (iPSC)-derived neurons following exposure to five neurotropic viruses: Herpes simpl...
Zi-Yi Li, Negin P. Martin, Jacob Epstein et al.· Scientific Data· 0 citations
ProtPipe2 is developed, a downstream proteomics analysis framework for mass spectrometry, Olink, and SomaScan data that is available as both an R package and an interactive web application and makes downstream analysis easier to perform, repeat, and review.
Jacob Epstein, Cory A. Weller, I. Kowal et al.· bioRxiv· 0 citations
Genome-wide association studies (GWAS) have identified many loci that contribute to the risk of neurodegenerative diseases. However, a persistent challenge in interpretation of GWAS is to break loci down to specific genes, variants, and cell types, and thus nominate disease mechanisms. Here, we used iPSC-derived cells...
X. Reed, Dominic J. Acri, A. Beilina et al.· bioRxiv· 0 citations
An integrated wet-lab and computational platform designed to overcome barriers to population-scale long-read RNA sequencing, providing a scalable, community-ready framework for isoform-resolved transcriptomics in neurodegeneration, aging, and complex brain disease.
C. Kouam, Jackson Mingle, Pilar Álvarez Jerez et al.· bioRxiv· 0 citations
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