Corinne H. Strawser

Estrogen promotes tumor phenotypes in ER+ and ER– breast cancer through UGDH-GPR30

Estrogen can promote aggressive tumor phenotypes in estrogen receptor–positive (ER+) breast cancer; however, ER– cell lines are not widely considered estrogen responsive. Noncanonical estrogen-stimulated pathways such as the membrane-bound G protein–coupled estrogen receptor (GPR30) can mediate migratory and proliferat...