Constanze Schmidt

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

This review provides an overview of recent advances in the development of multitarget drugs (MTDs) for cardiac diseases, with a particular focus on emerging molecular scaffolds and their pharmacological properties. We discuss the fundamental principles of cardiac polypharmacology and multitarget drug design, highlighti...

[Atrial fibrillation screening-reading the P-wave].

SGLT2 inhibition improves sarcomere contractile dysfunction in human models of dilated cardiomyopathy

It is found that a subcellular signaling pathway dysregulated in DCM CMs, clathrin-mediated endocytosis (CME)-dependent signaling, may be recovered by EMP treatment in DCM TPM1-L185F iPSC-CMs, which supports that EMP modulates aspects of CME-signaling, and contributes to restored sarcomere functions.