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Cong Zhang

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Aug 2026

Programmable Allosteric DNAzyme Coupled with CRISPR/Cas12a System for Multiplexed and Sensitive Detection of Extracellular Vesicle Derived MicroRNAs

A previously unrecognized feature of CRISPR/Cas12a is identified, in which incorporation of ribonucleotides into single stranded DNA targets modulates Cas12a activation efficiency, revealing a hybrid DNA/RNA-dependent regulation of Cas12a activity.

Xiang-Lan He, Le Wang, Cong Zhang et al. · 0 citations

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