Oct 2026
The landscape of polygenic score prediction accuracy and transportability across the phenome in ancestrally diverse populations
M. Lin, C. Arehart, S. N. K. Walker et al.
· medRxiv · 0 citations
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Sep 2026
Causal relationship between liver fat reduction and clinical outcomes in human genetic studies and randomized clinical trials of metabolic-dysfunction associated steatohepatitis
Reliance on invasive liver biopsy endpoints is a major limiting factor in new therapeutic development for metabolic dysfunction-associated steatohepatitis (MASH). While liver fat accumulation is considered a driver of early disease, liver fat reduction is not recognized as a surrogate endpoint by health authorities. He...
N. Verweij, G. Hindy, Q. Nguyen et al.
· medRxiv · 0 citations