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Author

Colin R. Goding

2 papers indexed here

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Open access Sep 2026

Inflammatory macrophages promote metastatic potential in Triple-negative Breast Cancer through Integrated Stress Response signaling

Triple-negative Breast Cancer (TNBC) is characterized by inflammatory myeloid infiltration and a high metastatic potential, however, the mechanisms by which macrophage-derived signals govern tumor cell plasticity remain poorly understood. Here, through patient transcriptomic analyses, in vitro functional studies, and...

Martina Crippa, Vincenzo Salemme, J. Chauhan et al. · 0 citations
Preprint Jul 2026

A quantitative model for the emergent population dynamics of the melanoma MITF rheostat

Cancer progression is driven by the ability of cells with identical driver mutations to adopt biologically distinct adaptive phenotypes. Yet the population dynamics implied by intratumour phenotypic heterogeneity is poorly understood. Melanoma is an excellent setting to study phenotype switching, in part because phenot...

Keith L. Chambers, Richard M. White, Colin R. Goding et al. · 0 citations

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