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Author

Colin Nixon

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Open access Sep 2026

Cholesterol and p53 promote senescence and systemic fibrosis in metabolic dysfunction-associated steatohepatitis

Local and systemic effects of hepatocellular p53 activity and cholesterol during MASH development are investigated, suggesting that dietary cholesterol promotes detrimental overactivation of p53 in MASH and facilitates fibrosis within the liver and distal organs.

Celine I. Wittke, Dale M. Watt, L. Butler et al. · 0 citations

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