Colin J. Daniel

Abstract A120: Tumor-intrinsic MYC promotes a skeletal muscle-involving wasting phenotype in pancreatic ductal adenocarcinoma

Cancer cachexia is defined by an ongoing loss of skeletal muscle mass, with or without loss of adipose tissue, and is particularly prevalent and severe in pancreatic ductal adenocarcinoma (PDAC). However, whether muscle and adipose wasting represent separable components of cachexia and are differentially shaped by tu...

Epigenetic progression of pancreatic cancer to aggressive subtypes involves alternate routes of lineage reprogramming in subtype-intermediate progenitor cells

Abstract A029: Chromatin accessibility profiling of human pancreatic tumors reveals epigenetic features of malignant and stromal cell subtypes

Pancreatic ductal adenocarcinoma (PDAC) disease progression involves complex cell state transitions in both malignant and non-malignant populations within the tumor microenvironment. To uncover PDAC cell states and epigenetic features associated with clinical outcome, we profiled 40 tumor samples (33 primary tumors a...

The post-transcriptional regulator HuR promotes immune evasion in pancreatic ductal adenocarcinoma.

Overall, it is found that the post-transcriptional regulator HuR facilitates immune evasion in PDAC by constraining T-cell function, identifying HuR blockade as a promising therapeutic strategy in combination with immunotherapies.