Molecular Binding in Supramolecular Fibrillar Biomolecules.
Amyloid-β (Aβ) fibrils are biopolymer structures associated with the onset of Alzheimer's disease. Quantitative analyses of the interactions between Aβ fibrils and ligands, including dissociation constant (Kd) and binding stoichiometry (n), are crucial. In this paper, two independent-variable binding assays were simult...