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Author

Clive S. Barker

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Open access Sep 2026

Lsp2 links early-life diet to adult translation and lifespan in Drosophila

Nearly a century ago, restricting diet during early-life periods was suggested to extend lifespan in rats and in Daphnia1,2. The effect of juvenile diet on adult physiology and lifespan has subsequently been described in other model organisms, including fruit flies3, 4–5 and mice6, 7–8; however, its mechanism remains p...

Hina Kosakamoto, Rina Okada, Clive S. Barker et al. · 2 citations
Open access Aug 2026

SPIN1 selectively silences evolutionarily young transposable elements through chromatin regulation

SPIN1 uses a histone-state-based mechanism to identify and repress young TEs in pluripotent cells, mechanistically distinct from its germline mode in which SPIN1 cooperates with the PIWI–piRNA pathway to promote DNA methylation, illustrating how a single histone reader engages distinct silencing machineries across cell...

Hiromi Yamada, Chikara Takeuchi, Clive S. Barker et al. · 0 citations

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