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Author

Cleophas Cheruiyot

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Open access Jul 2026

SGLT2 inhibition improves sarcomere contractile dysfunction in human models of dilated cardiomyopathy

It is found that a subcellular signaling pathway dysregulated in DCM CMs, clathrin-mediated endocytosis (CME)-dependent signaling, may be recovered by EMP treatment in DCM TPM1-L185F iPSC-CMs, which supports that EMP modulates aspects of CME-signaling, and contributes to restored sarcomere functions.

Daria Plota, H. N. Saleem, K. Lin et al. · 0 citations

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