Open access
Aug 2026
Expansion of functional human long-term HSCs through restraining excessive cell cycle activation.
A niche-mimetic culture system that integrates intrinsic and extrinsic bone marrow regulatory cues, including pharmacologic inhibition of the m6A reader YTHDF2 using the small molecule Y13-27, a three-dimensional microenvironment, and N-cadherin-mediated adhesion is established that preserves transcriptional and epigen...
Xinjian Mao, Ning Zhang, Xi C. He et al.
· Blood · 0 citations