Clara K. T. Koh

Targeting NOX1 to Reprogram T Cell Activation and Metabolism for Enhanced CAR T Efficacy 2251163

T-cell exhaustion is a critical roadblock to achieving durable remission with adoptive cell therapies. The immunosuppressive tumor microenvironment limits T-cell persistence and function, demanding new reprogramming techniques. Our genome-wide CRISPR screen in CD8+ T cells identified NOX1 as a novel, negative eff...