Open access
Jul 2026
AAV delivered lysosome-targeting chimeras mediate sustained antibody depletion in vivo
This work developed genetically-encoded lysosome targeting chimeras (GELYTACs) that target circulating IgGs for clearance and degradation and establishes GELYTACs as a possible therapeutic modality that is deliverable using genetic medicine approaches.
J. L. Yang, K. Y. Loh, Cindy R. Sandoval Espinoza et al.
· bioRxiv · 0 citations