Transcriptome-Inspired Spiking Simulations Uncover Human-Specific Prefrontal Dynamics and Provide a Mechanistic Platform for Species-Appropriate Disease Modeling
Whole-brain transcriptomic atlases are now widely available, yet computational neural models are almost exclusively parameterized from rodent data and used to infer human brain function, an extrapolation whose cost remains unquantified. To address this, we constructed a biophysically detailed, conductance-based Hodgkin...