Systematic Evaluation of Competing Brain Transcriptomic Representations Reveals Reciprocal Patterns Across Heterogeneous Contexts
Two representations of cross-context brain transcriptomic organization are compared: a transcriptome-wide global-axis model and a low-dimensional reciprocal model, motivating a low-dimensional reciprocal representation as an exploratory framework while emphasizing context dependence, cohort dependence, and heterogeneity.