Author

Chunliang Li

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Open access Aug 2026

MBNL1 hijacks a structured single-stranded distal DNA element to sustain FLT3 expression in KMT2A-rearranged leukemias

Findings implicate MBNL1 as a distinct FLT3 activator by recognizing a structured enhancer ssDNA element, highlighting an unexpected role for RNA binding proteins in transcriptional regulation through direct ssDNA recognition.

Meixia Che, Shaela Fields, Siqi Yi et al. · Science Advances · 0 citations

Open access Jul 2026

Rbm5 sustains leukemia stem cells through a Myc-driven transcriptional circuitry.

It is reported that an unappreciated RNA-binding protein, Rbm5, selectively promotes murine leukemogenesis, maintains LSC self-renewal in vivo, and is dispensable for normal hematopoiesis.

Mengli Zhang, Shaela Fields, Qiong Zhang et al. · Leukemia · 0 citations

Jul 2026

An epigenetic polarity governing T cell tolerance for commensal microbiota 2250947

The study depicts an epigenetic polarity governing Treg-mediated immune tolerance, highlighting a fundamental asymmetry at the epigenetic level that differentially regulates Treg and conventional T cells.

Wenjun Huang, Yongqiang Feng, Jun Li et al. · Journal of Immunology · 0 citations