Cell membrane coating offers a biomimetic strategy for drug delivery by combining the biological functions of natural membranes with the tunable properties of synthetic nanoparticles (NPs). The coating process influences membrane coverage and the biological performance of the resulting particles, making the selection o...
Moataz B. Zewail, Yun Liu, Yi-Long Fan et al.· Aggregate· 0 citations
Particle-based artificial antigen-presenting cells (aAPCs) are widely used for ex vivo T cell activation, but rigid, high-avidity stimulation can promote differentiation and exhaustion, reducing therapeutic efficacy. Because T cells sense mechanical forces through the T cell receptor, we engineered nanocapsule aAPCs wi...
The immunosuppressive tumor microenvironment (TME) remains one of the main obstacles that limit responsiveness to immunotherapy. Recently, lipid nanoparticles carrying messenger RNA (mRNA) have emerged as a promising strategy to modulate the immunosuppressive TME, with the ultimate goal of sustaining anticancer immunit...
Rui Chen, Letao Xu, Alexander H. Staudacher et al.· Science Advances· 1 citation
An in vitro model of human liver with functional integrity would advance liver research and enable personalized therapeutics. A microfluidic liver-on-a-chip can generate a functional hepatobiliary network using human liver cells and recapitulate blood circulation and bile excretion. However, many current microfluidic l...
Anastasia Brooks, Haotian Yang, D. Barkauskas et al.· Cell Reports Methods· 0 citations
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