Ultrasound (US)-triggered sonodynamic therapy (SDT) combined with immunotherapy shows considerable promise, yet its therapeutic efficacy remains constrained by insufficient intratumoral drug activation and limited immunogenicity. Herein, we report a self-amplifying US-responsive nanoplatform (PMB@R848) for synergistic...
Yu Zhang, Xin-Ming M. Liu, Jie Chen et al.· Advances in Materials· 0 citations
An injectable sonodynamic hydrogel (POPP gel) that captures bacteria via a nanofibrous cationic network and kills them upon ultrasound activation is developed, which reduces bacterial burden and accelerates tissue repair in murine infected wound and burn models.
Yongchang Tian, Rong Zhang, Xing-Jun Zhao et al.· Acta Biomaterialia· 0 citations
In bacterial-induced mouse models of epidermal and keratitis infections, cHH8-6 effectively reduces the bacterial count at the infection site with negligible in vivo toxicity, and due to its unique mechanism, cHH8-6 is less likely to induce bacterial resistance compared to clinical antibiotics.
Zhe Zong, Guowenlie Gao, Pengqi Wan et al.· Biomaterials Science· 0 citations
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