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Author

Chunping Tang

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Aug 2026

Feature-Based Analysis of MS2 Data Reveals a Skeleton-Level Chemical Space and Enables Discovery of Sesquiterpenes with Unprecedented Skeletons.

Natural products bearing novel skeletons expand accessible chemical space and may inspire future biological discovery, yet their identification still relies largely on chance. This limitation stems largely from prevailing strategies for representing and interpreting MS2 data and not simply from spectral quality or algo...

Chenlan Shu, Wanyu Huang, Zhuohao Yu et al. · 0 citations
Open access Aug 2026

A bitter melon natural compound ameliorates the myotonic dystrophy type 1 skeletal muscle phenotype in a sex-specific manner

Results indicate that sustained AMPK activation with BMC-25 confers multifaceted benefits to DM1 skeletal muscle by improving core DM1 pathogenic features in a sex-dependent manner, and highlights the potential of natural compounds like BMCs as novel, promising and accessible therapeutics for the DM1 muscle pathology.

Shatha A. Atieh, Chimène Fahmi, Jia Liu et al. · 0 citations

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